Major Depressive Disorder in People living with Chronic pain

Key things to know What the evidence shows
How common is it? 36.7% global pooled MDD
Is it more common among people living with chronic pain? Much higher than controls
Are people living with chronic pain at higher risk? Yes
How much higher is the risk? 36.7% MDD vs 10.1% controls
How often can it be missed? High because sleep, fatigue and function overlap pain
Does it show up differently among people living with chronic pain? Somewhat
How might it look different? Pain–sleep–fatigue–activity cycle may obscure MDD
What commonly occurs alongside it? Anxiety; sleep disorders
What can it be confused with? Pain-related fatigue/sleep problems; medication effects
Common screening tool PHQ-9
Separate screening tool for people living with chronic pain None
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