Major Depressive Disorder in Women Navigating Infertility

Not established What the evidence shows
How common is it? 22.9% global MDD among infertile women
Is it more common among women navigating infertility? Higher than general-population burden
Are women navigating infertility at higher risk? Yes
How much higher is the risk? 22.9% pooled MDD prevalence; comparative risk ratio not established from this estimate
How often can it be missed? Moderate–high
Does it show up differently among women navigating infertility? No distinct MDD phenotype established
How might it look different? Fertility-treatment distress, grief and uncertainty can dominate context
What commonly occurs alongside it? Anxiety; stress
What can it be confused with? Adjustment disorder; anxiety
Common screening tool PHQ-9
Separate screening tool for women navigating infertility None specifically for MDD
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